International Journal of Applied Microbiology and Biotechnology Research
ISSN: 2053-1818
Vol. 7(7), pp. 95-105, August, 2019

Characterization of gut microbiota dysbiosis induced by weaning and diarrhea in Tibetan piglets

Ping Hu1, Feng Wang2 and Xi-Shan Xiao1*

1Beijing Vocational College of Agriculture, Beijing, 102400, China.
2Allwegene Technology Inc. Beijing, 102200, China.

*To whom correspondence should be addressed. E-mail:,

Received 28 May, 2019; Received in revised form 26 June, 2019; Accepted 02 July, 2019.


Weaning, Diarrhea, Tibetan pigs, Dysbiosis, V3-V4 regions.

Tibetan pig is an important native pig breed surrounding the Qinghai-Tibet Plateau of China. The dysbiosis of gut microbiota in piglets induced by the weaning transition, which resulted in diarrhea commonly, could decrease the feed intake and weight gain. Uncovering of the turbulence and dysbiosis of gut microbiome related to post-weaning diarrheal piglets were conducted based on sequencing V3-V4 hypervariable regions of 16S rDNA using Miseq platform in this study. A total of 49 piglets from two farms were divided into four groups, pre-weaning normal group, pre-weaning diarrheal group, post-weaning normal group and post-weaning diarrheal group. The results obtained reveal that weaning increased the bacterial diversity and decreased the composition of Lactobacillus. In non-weaned piglets, diarrhea decreased the bacterial diversity. However, in post-weaning piglets, bacterial diversity, richness and compositions were not influenced by diarrhea. Alloprevotella belonging to Prevotellaceae, and Streptococcaceae were microbiological markers for post-weaning diarrhea. The results obtained are not in agreement with other studies published previously. This study may provide a new insight into understanding the dysbiosis of gut microbiome caused by weaning and diarrhea.

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