International Journal of Applied Microbiology and Biotechnology Research
ISSN: 2053-1818
Vol. 7(2), pp. 18-23, March, 2019

Effects of Irvingia species leaf extract on Streptococcus pneumoniae infected albino rats

Arikekpar Ibemologi1*, Alade Tolulupe1 and Langley A. Orutugu2

1Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Amassoma, P. M. B. 071, Bayelsa State, Nigeria.
2Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Amassoma, Wilberforce Island, Nigeria.

*To whom correspondence should be addressed. E-mail:

Received 23 October, 2018; Received in revised form 10 December, 2018; Accepted 13 December, 2018.


Antimicrobial activity, Post-infection, Irvingia sp., Oral administration, Health benefits.

Streptococcus pneumoniae causes pneumonia and bacterial meningitis, and bacteremia in children. Irvingia sp. or African Bush Mango has nutritional and health benefits and their leaf extracts and other parts have been documented to possess antimicrobial activity, which can be exploited to ameliorate the scourge of antibiotics resistance. In this study, 30 out of 35 albino rats were intraperitoneally challenged with S. pneumoniae, followed by oral administration of leaf extract of Irvingia sp. The rats exhibited sluggishness, ruffled fur, inappetence and hunch back posture, but recovered from the fourth day after oral administration of Irvingia sp. leaf extract. The mean body weights of the rats were 175±1.9 g and 176±1.5 g in the test and the control groups, respectively on the first day of the experiment. The mean body weight of the test group (173±7 g) was lower than the control group (182±40.5 g) on the sixth day of post-infection (P = 0.65). The mean value of food intake by the rats for base line (27.95±5.3g) was higher than the third day (17.35±2.2g) corresponding with inappetence observed in the rats in the test group.

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