International Journal of Modern Biological Research
ISSN: 2053-180X
Vol. 6(1), pp. 1-8, January 2018



Chemopreventive potential of Annona squamosa leaves extract in Swiss albino mice

Agrawal, R. C*, Singh, Snehal and Maheshwari, S. K.

Department of Research, Priyamvada Birla Cancer Research Institute, Satna, India.

*To whom correspondence should be addressed. E-mail: rcagrawal60@yahoo.com.

Received 18 November, 2017; Received in revised form 16 December, 2017; Accepted 22 December, 2017.

Abstract


Keywords:
Papilloma, Micronucleus assay, Chromosomal aberrations, Bone marrow antibacterial, Antimutagenicity.


The effect of Annona squamosa leaves extract against 7,12-dimethylbenz(a)anthracene (DMBA) induced papillomagenesis in Swiss albino mice was studied. The methanolic extract of A. squamosa was analyzed for chemopreventive activity. Chemopreventive activity was evaluated by employing two stage protocol, consisting of initiation with a single topical application of a carcinogen (DMBA) followed by a promoter (croton oil), twice a week. A significant reduction in tumor incidence, tumor burden and cumulative number of papillomas was observed, along with a significant increase in average latent period in mice treated topically with A. squamosa extract as compared to the control group treated with DMBA and croton oil alone. The anticarcinogenic activity of A. squamosa extract was also observed in Melanoma tumour model. The antibacterial and antimutagenic activities of Annona leaves extract were also observed. The different dose of A. squamosa leaves extract showed dose dependent protection of chromosomal aberrations and micronucleus formations in bone marrow of Swiss albino mice. The above studies revealed information about the prevention of cancer. Therefore, the study is immensely important in future drug development programs for cancer treatment.

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