Journal of Engineering and Manufacturing Technology
ISSN: 2053-3535
Vol. 6(3), pp. 38-46, May 2018



Solubility of Pranlukast in isopropanol and isopropanol-N,N-dimethylformamide binary solvents

Minghuang Hong**, Kai Wang**, Sai Guo and Guobin Ren*

Laboratory of Pharmaceutical Crystal Engineering and Technology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.

*To whom correspondence should be addressed. E-mail: rgb@ecust.edu.cn.
**These authors contributed equally to this work.

Received 13 March, 2018; Received in revised form 12 April, 2018; Accepted 16 April, 2018.

Abstract


Keywords:
Pranlukast, Isopropanol-N,N-dimethylformamide, Thermodynamics properties.


The solubility of Pranlukast in isopropanol and isopropanol-N,N-dimethylformamide binary solvents from 293.15 to 333.15 K at atmospheric pressure was determined by dynamic laser method. The results obtained show that the solubility of Pranlukast increased with increasing temperature in a certain solvent system, and also increased with increasing mole fraction of N,N-dimethylformamide in the binary solvent systems at a specific temperature. Experimental data were correlated using the modified Apelblat model, the CNIBS/Redlich-Kister model and the 3D Jouyban-Acree model. The results obtained suggest that all the models provided good fit, with the most accurate prediction obtained from the modified Apelblat model. Thermodynamic properties including standard enthalpy, standard entropy and molar Gibbs free energy change of solution were calculated as well, which indicated that the dissolution process was endothermic and non-spontaneous.

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