Journal of Medicinal Plant and Herbal Therapy Research
ISSN: 2053-1826
Vol. 6(1), pp. 9-18, February 2018



Di-(2-ethylhexyl) phthalate (DEHP) and ovarian physiology: A brief review of therapeutic potential of Asparagus racemosus on DEHP- induced toxicity

Anima Tripathi1, Pawan K. Dubey2, Vivek K. Pandey2, Garima Tripathi3, Sangeeta Hazarika4, K. Sairam4, A. N. Sahu4*

1Department of Zoology, MMV, Banaras Hindu University, Varanasi-221005, India.
2Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi-221005, India.
3Department of Chemistry, TNB College, Tilka Manjhi University, Bhagalpur, Bihar-812007, India.
4Department of Pharmaceutical Engineering and Technology IIT- BHU Varanasi-221005, India.

*To whom correspondence should be addressed. E-mail: pawandubey1981@gmail.com, niluskc@gmail.com.

Received 09 January, 2018; Received in revised form 09 February, 2018; Accepted 13 February, 2018.

Abstract


Keywords:
DEHP, Ovary, Infertility, Herbal drug, Shatavari.

Exposures to environmental contaminants have been shown to disrupt endocrine function by inhibiting or stimulating the hormone production and thus affecting the functions that these hormones control. Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical (EDC) and a potent environmental as well as reproductive toxicant that poses a great impact on human health severally affecting fertility in both male and female. This review discusses the adverse effect of selected EDCs that is DEHP on the ovarian physiology. Furthermore, this review also highlights one of the herbal drugs, that is, Asparagus racemosus (Shatavari) that can be utilized to minimize the DEHP induced toxicity. This approach appears to hold great promise for treating many reproductive abnormalities as common people cannot afford the cost of assisted reproduction techniques (ARTs) such as Di-(2-ethylhexyl) phthalate (IVF), intercytoplasmic sperm injection (ICSI) procedures. In addition, it will delineate a roadmap for using herbal based therapies to cure various incurable reproductive diseases.

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