Journal of Medicinal Plant and Herbal Therapy Research
ISSN: 2053-1826
Vol. 7(1), pp. 1-37, April 2020
doi.org/10.33500/jmphtr.2020.7.001

Evaluation of anti-fungal activity of fractional extracts of Hugonia platysepala on the germs responsible for candidiases in HIV-infected people

COULIBALY Ousmane^1,2,4*, DOSSO Mamadou³, SORO Yaya⁴, IRA Bonouman¹ and YAPO-CREZOIT Chiaye²

¹Laboratory of Mycology and Parasitology of Pasteur Institute, BP 490, Abidjan 01-Ivory Coast.
²Immunology Laboratory of Pasteur Institute BP 490 Abidjan 01- Ivory Coast.
³Department of Biochemistry-Genetics, University Gon Coulibaly, BP 1328 Korhogo - Ivory Coast.
⁴Laboratory of Chemical, Food and Environmental Processes, Science of INPHB, BP 1313 Yamoussoukro - Ivory Coast.

*To whom correspondence should be addressed. E-mail: coulibalyous1@gmail.com.

Received 26 November, 2019; Received in revised form 18 February, 2020; Accepted 20 February, 2020.

Abstract

Keywords:
Candidiases, Anongal, Fractions, HIV/AIDS, Hugonia platysepala.

Candidiases are opportunistic AIDS diseases that result in high mortality and morbidity rates among people living with HIV. Their treatment is particularly difficult because of the resistance, toxicity and high cost of conventional anti-fungals. Facing this problem of treating these candidiases in the context of poverty, this study was conducted with the aim to look into the traditional pharmacopoeia plants with anti-fungal properties capable of treating them effectively and at a low cost. For this purpose, four fractions of the alcoholic extract of Hugonia platysepala were extracted and tested in vitro on Candida albicans resistant strain by the method of double dilution and diffusion in solid medium. The fraction of acetate (Face) was the most active with a minimal inhibitor concentration (MIC) of 0, 78 mg/ml, a minimal fongicide concentration (MFC) of 25 mg/ml and a diameter of inhibition of 13 mm which is higher than the diameter of amphotericin B and fluconazole. Phytochemical screening revealed that this Face fraction of H. platysepala contains terpenes, polyphenols and tannins that are believed to be responsible for its anti-fungal pharmacological properties. Thus, the use of this plant in traditional medicine is an asset in the treatment of certain candidiases including those that affect immuno-suppressed.